|
|
Build Your Online Product Catalogs?
| Product Name: |
Gentianine
|
| Supply Ability: |
|
| Related proudcts |
|
| Specifications |
50-98% |
| Price Term: |
|
| Port of loading: |
|
| Minimum Order |
|
| Unit Price: |
|
|
The alkaloid natural base from genciana macrophylla pall ,white crystalline, Molecular: c10H9No2 ,molecular weight: 175.18,dissolved in chloroform and aether
The co***ny can produce the extract containing different purity according to the customers¡¯ requirements.
This study was undertaken to elucidate the mechanism of anti-inflammatory action of gentianine, a constituent of Gentiana Macrophylla. The effects of gentianine on lipopolysacharide (LPS)-induced production of pro-inflammatory cytokines were investigated in male Sprague-Dawley rats. For the first time, we found that oral administration of gentianine (10-100 mg/kg) suppressed the increases in tumor necrosis factor-alpha (TNF-alpha) (ED(50), 37.7 mg/kg) and interleukin (IL)-6 (ED(50), 38.5 mg/kg) in the sera from the rats challenged with bacterial LPS (100 microg/kg; i.p.). However, LPS induced production of other interleukins, such as IL-alpha, was not significantly altered by gentianine. These results suggest that the potential anti-inflammatory action of gentianine might be at least partly based on the suppressed production of TNF-alpha and IL-6.
|
| Company: |
Shaanxi Supplier Biological Technology Co., Ltd.
|
| Contact: |
Ms. zhang lily |
| Address: |
dianzi sanlu |
| Postcode: |
710065 |
| Tel: |
86 29 82139722 |
| Fax: |
86 29 81873931 |
| E-mail: |
|
|
|
|
Home
